UNDERSTANDING SPHINGOSINE 1-PHOSPHATE METABOLISM IN CANCER & AGING
Sphingolipids have long been known to play important roles in cellular metabolism and membrane biology, but the notion of sphingolipids as cellular signaling molecules has gained recognition only the last two decades. Bioactive sphingolipids, including ceramide, sphingosine and sphingosine 1-phosphate (S1P) are now appreciated as key regulators of multiple cellular processes, including cell proliferation, differentiation, apoptosis, and immune responses. Our Lab is studying the role of S1P metabolism in cancer and aging.
Sphingosine 1-Phosphate, G protein coupled receptors (GPCRs), Alzheimer's disease, prostate cancer, renal cell carcinoma, bladder cancer, osteosarcoma, chemotherapy, photodynamic therapy, hypoxia, bone microenvironment, metastasis, invasion/migration, mitosis, necroptosis
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IPBS, Institute of Pharmacology and Structural Biology
CNRS UMR 5089
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